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Originally developed as a veterinary drug to help improve appetite and lean muscle mass in racehorses, Equipoise was marketed as Boldenone and approved for human consumption during the 60sby the FDA. A 2012 study in the Journal of Agricultural and Food Chemistry found that equipoise inhibits the growth of some of the same gut microbiome strains that can lead to obesity and diabetes. And a 2015 Danish research paper found that Equipoise decreased the level of a peptide called prothrombin, which is a marker of cardiovascular risk in humans. Now it looks like Boldenone's side effects are getting people's attention too. According to the Mayo Clinic, Boldenone is generally safe for those who are healthy and do not develop diabetes, especially if taken from the diet. "Most people who have been taking this treatment for at least several years have stopped taking it," Dr. John A. Murray, an associate professor at the University of California Davis School of Medicine and the director of the Center for Cardiovascular Care Research, told Reuters Health. Boldenone is currently available only in Europe, but Murray notes that it might be more widely available than originally thought. Other treatments using stimulants to treat obesity, like Nizoral or Fenbendazole, have the potential to affect the gut microbiome and can affect the development of disease, but they can be highly risky. And there's also the issue of how this work will be regulated. "There's a long history of FDA approval for drugs that treat obesity, including drugs with stimulants such as Fenbendazole," Murray noted. "With regards to other drugs for weight loss, there's also a long history of FDA approval for drugs that treat obesity, including drugs with stimulants such as Nizoral and Fenbendazole." And as Boldenone gets its name back to some degree, other pharmaceutical companies, including Merck, are also exploring the potential for these so-called gut-busting drugs. Related Article: